This graph details the top 5 reasons why volunteers participate in clinical trials. These include:
- To advance medicine: 51%
-
To find a better treatment for my condition: 46%
-
To help others with my condition: 39%
-
To earn extra money: 36%
-
My doctor recommended it: 31%
Source: Harris Interative, 2005 |
In 2001, out of 5,348 research participant interviewed, 84% responded that they would participate in a clinical trial again, where 16% would not. In 2005, out of 2,261 research participants, 88% said they would participate in a clinical trial again, where only 12% said they would not.
Source: Harris Interactive |
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In 2006, there were 2,405 volunteers participating in clinical trials.
- Government-Funded Clinical Trials: 775
- Industry-Funded Clinical Trials (Phases I-III): 880
- Industry-Funded Clinical Trials (Phase IV): 750
Source: CISCRP and NIH, 2007 |
Between 2000 and 2005, total spending on biopharmaceutical research and development has increased slightly each year.
Source: Tufts CSDD, 2006 based on NIH and PhRMA data |
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In 2005, these organizations had the most drugs in Research and Development:
- Sanofi-Aventis: 325
- GlaxoSmithKline: 289
- Roche: 263
- Pfizer: 222
- Novartis: 187
Source: IMS Lifecycle R&D Focus, 2005 |
This graph charts the number of Drugs in the Research and Development pipeline worldwide since 1995.
1995: 5,492
1997: 5,786
1999: 7,494
2001: 8,912
2003: 9,924
2005: 12,423
2007 (predicted): 14,653
Source: IMS Lifecycle, R&D Focus |
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This graph compares the total cost of developing a drug which includes out-of-pocket costs and the cost of capital between 1970s, 1980s, 1990s and 2000s.
Source: Tufts CSDD, the Office of Technology Assessment, 2001 |
This graph details how long the it takes to develop a new drug from Discovery through to the New Drug Application submission.
Source: FDA, Tufts CSDD |
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This chart details how many drugs have success in each stage of drug development. As shown, a high number of drugs enter the Discovery and Screening stage, but significantly less drugs go beyond Pre-Clinical Testing.
Source: PhRMA, Tufts CSDD |
This graph details the average time in years it takes to develop a drug from the IND (Investigational New Drug) Filing to the NDA (New Drug Application) Submission.
| Therapeutic Area |
Fastest 5
Companies |
Middle 5
Companies |
Slowest 5
Companies |
Average All
Companies |
| Anesthetic/Analgesic |
10.7 yrs |
4.4 yrs |
4.8 yrs |
5.82 yrs |
| Anti-infective |
3.9 |
5.9 |
6.9 |
5.5 |
| Anti-neoplastic |
5.5 |
6.9 |
9.2 |
6.9 |
| Cardiovascular |
5.1 |
5.6 |
6 |
6.2 |
| CNS |
NA |
NA |
13.2 |
8.6 |
| Endocrine |
4.6 |
5.7 |
9.7 |
7.1 |
| Gastrointerstinal |
NA |
9.8 |
9.4 |
7.9 |
| Immunologic |
5.3 |
11.4 |
8.1 |
5.45 |
| Miscellaneous |
4.8 |
6 |
10.5 |
6.2 |
Source: Tufts CSDD, 2006 |
This graph provides several examples of the size and scope of clinical trials for a variety of drugs and medical conditions. Each trial takes several years in clinical trials and have different number of study volunteers.
Source: FDA |
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In 2004, Thomson CenterWatch reported on the distribution of volunteer participation by clinical phases. A high number of study volunteers participated in Phase III trials (65%) where as Phase II had 21% and Phase I had 14%. |
In 2004, Thomson CenterWatch surveyed 1,050 study volunteers regarding the professionalism of the clinical research staff and 84% responded the staff was very professional. |
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In 2004, Thomson CenterWatch surveyed 1,050 study volunteers regarding the quality of care they received in clinical trials and 72% said they received 'excellent' care. 18% responded they received 'good' care. |
Active clinical trials which take place throughout the United States are detailed by geographic region in this graph.
- South: 42%
- Northeast: 19.5%
- West: 19.2%
- Midwest: 19.2%
Source: Tufts CSDD, 2006 |
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This graph shows the top 5 ways people learn about clinical trials:
- The media: 38%
- Internet: 22%
- My Doctor: 14%
- Friends: 11%
- Family: 9%
Source: Harris Interactive, 2005 |
This chart lists examples of compensation offered for volunteer participation in clinical trials.
- Bipolar Disorder - 6 weeks/10 visits, investigational drug - $300
- Diabetes - 8 weeks/4 visits, investigational drug plus MRIs - $1,860
- Psoriasis - 6 weeks/4 visits, investigational drug - $160
- Hormone Replacement - 7 weeks - $600
- Overactive Bladder - investigational delivery system of FDA approved drug - $500
- Obstructive Sleep Apnea - 6 months, investigational airway pressure treatment - $500
- High Glycerides Study (NY) - 16 weeks/10 visits, oral medication - $300
- Elevated Triglcerides (MI) - 4.5 months/7 visits, oral medication - $280
Source: Listings in major newspapers |
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This chart lists the top areas where drugs are in clinical trials specifically for older adults (age 65+):
| |
|
Number of Drugs in Trials |
| Lung/Respiratory Illnesses |
|
52 |
| Diabetes |
|
48 |
| Pain |
|
41 |
| Rheumatoid Arthritis |
|
38 |
| Alzheimer's Disease |
|
27 |
| Gastrointestinal Disorders |
|
23 |
| Eye Disorders |
|
23 |
| Osteoporosis |
|
20 |
| Depression |
|
19 |
| Parkinson's Disease |
|
17 |
|
